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How do you take estradiol? If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor. You may take it with food or right after a meal to prevent stomach upset. If you are taking the extended-release tablets, do not crush, chew, or dissolve them.
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How long does Premarin cream take to work? In a clinical study, patients taking Premarin Vaginal Cream felt significant relief of moderate to severe painful intercourse due to menopause at 12 weeks.
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